Identification of B cell subsets based on antigen receptor sequences using deep learning

Identification of B cell subsets based on antigen receptor sequences using deep learning

B cell receptors (BCRs) denote antigen specificity, while corresponding cell subsets indicate B cell functionality. Since each B cell uniquely encodes this combination, physical isolation and subsequent processing of individual B cells become indispensable to identify both attributes. However, this...

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Bibliographic Details
Main Authors: Hyunho Lee, Kyoungseob Shin, Yongju Lee, Soobin Lee, Seungyoun Lee, Eunjae Lee, Seung Woo Kim, Ha Young Shin, Jong Hoon Kim, Junho Chung, Sunghoon Kwon
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
B cell receptor
B cell subset
deep learning
integrated gradients
somatic hypermutation
next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342285/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342285/full

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