Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation
Background: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-environment/lifestyle interaction in obesity is based on the concept of moderatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-03-01
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| Series: | Lifestyle Genomics |
| Online Access: | https://www.karger.com/Article/FullText/523813 |
| _version_ | 1811245537812283392 |
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| author | Louis Pérusse Raphaëlle Jacob Vicky Drapeau Clare Llewellyn Benoit J Arsenault Alexandre Bureau Marie-Ève Labonté Angelo Tremblay Marie-Claude Vohl |
| author_facet | Louis Pérusse Raphaëlle Jacob Vicky Drapeau Clare Llewellyn Benoit J Arsenault Alexandre Bureau Marie-Ève Labonté Angelo Tremblay Marie-Claude Vohl |
| author_sort | Louis Pérusse |
| collection | DOAJ |
| description | Background: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-environment/lifestyle interaction in obesity is based on the concept of moderation, or effect modification. Another approach called mediation analysis can be used to investigate gene-environment interaction in obesity. The objective of this review article is to explain the differences between the concepts of moderation and mediation and summarize the studies that have used mediation analysis to support the role of eating or lifestyle behaviors as putative mediators of genetic susceptibility to obesity.
Summary: Moderation is used to determine whether the effect of an exposure (genes associated with obesity) on an outcome (obesity phenotype) differs in magnitude and/or direction across the spectrum of environmental exposure. Mediation analysis is used to assess the extent to which the effect of the exposure on the outcome is explained by a given set of hypothesized mediators with the aim of understanding how the exposure could lead to the outcome. In comparison with moderation, relatively few studies used mediation analyses to investigate gene-environment in obesity. Most studies found evidence that traits related to appetite or eating behaviors partly mediated genetic susceptibility to obesity in either children or adults.
Key messages: Moderation and mediation represent two complementary approaches to investigate gene-environment interaction in obesity and address different research questions pertaining to the cause-effect relationship between genetic susceptibility to obesity and various obesity outcomes. More studies relying on mediation are needed to better understand the role eating and lifestyle habits in mediating genetic susceptibility to obesity. |
| first_indexed | 2024-04-12T14:40:25Z |
| format | Article |
| id | doaj.art-16c1266a120d4d7aacae1765be4e9e6c |
| institution | Directory Open Access Journal |
| issn | 2504-3161 2504-3188 |
| language | English |
| last_indexed | 2024-04-12T14:40:25Z |
| publishDate | 2022-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Lifestyle Genomics |
| spelling | doaj.art-16c1266a120d4d7aacae1765be4e9e6c2022-12-22T03:28:50ZengKarger PublishersLifestyle Genomics2504-31612504-31882022-03-0110.1159/000523813523813Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderationLouis Pérussehttps://orcid.org/0000-0001-6440-9698Raphaëlle JacobVicky DrapeauClare LlewellynBenoit J Arsenaulthttps://orcid.org/0000-0003-2240-8456Alexandre BureauMarie-Ève Labontéhttps://orcid.org/0000-0001-9745-0443Angelo TremblayMarie-Claude VohlBackground: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-environment/lifestyle interaction in obesity is based on the concept of moderation, or effect modification. Another approach called mediation analysis can be used to investigate gene-environment interaction in obesity. The objective of this review article is to explain the differences between the concepts of moderation and mediation and summarize the studies that have used mediation analysis to support the role of eating or lifestyle behaviors as putative mediators of genetic susceptibility to obesity. Summary: Moderation is used to determine whether the effect of an exposure (genes associated with obesity) on an outcome (obesity phenotype) differs in magnitude and/or direction across the spectrum of environmental exposure. Mediation analysis is used to assess the extent to which the effect of the exposure on the outcome is explained by a given set of hypothesized mediators with the aim of understanding how the exposure could lead to the outcome. In comparison with moderation, relatively few studies used mediation analyses to investigate gene-environment in obesity. Most studies found evidence that traits related to appetite or eating behaviors partly mediated genetic susceptibility to obesity in either children or adults. Key messages: Moderation and mediation represent two complementary approaches to investigate gene-environment interaction in obesity and address different research questions pertaining to the cause-effect relationship between genetic susceptibility to obesity and various obesity outcomes. More studies relying on mediation are needed to better understand the role eating and lifestyle habits in mediating genetic susceptibility to obesity.https://www.karger.com/Article/FullText/523813 |
| spellingShingle | Louis Pérusse Raphaëlle Jacob Vicky Drapeau Clare Llewellyn Benoit J Arsenault Alexandre Bureau Marie-Ève Labonté Angelo Tremblay Marie-Claude Vohl Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation Lifestyle Genomics |
| title | Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation |
| title_full | Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation |
| title_fullStr | Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation |
| title_full_unstemmed | Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation |
| title_short | Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation |
| title_sort | understanding gene lifestyle interaction in obesity the role of mediation versus moderation |
| url | https://www.karger.com/Article/FullText/523813 |
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