Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation. Our data show that nuclei in differentiated bovi...

Full description

Bibliographic Details
Main Authors: Su-Jin Heo, Tristan P Driscoll, Stephen D Thorpe, Nandan L Nerurkar, Brendon M Baker, Michael T Yang, Christopher S Chen, David A Lee, Robert L Mauck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
stem cells
nuclear mechanics
mechanotransduction
Online Access:https://elifesciences.org/articles/18207

Internet

https://elifesciences.org/articles/18207

Similar Items