Astroglial S100B Secretion Is Mediated by Ca<sup>2+</sup> Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues

Astroglial S100B Secretion Is Mediated by Ca<sup>2+</sup> Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues

S100B, a homodimeric Ca<sup>2+</sup>-binding protein, is produced and secreted by astrocytes, and its extracellular levels have been used as a glial marker in brain damage and neurodegenerative and psychiatric diseases; however, its mechanism of secretion is elusive. We used primary astr...

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Bibliographic Details
Main Authors: Marina C. Leite, Fabiana Galland, Maria Cristina Guerra, Letícia Rodrigues, Jéssica Taday, Priscila T. Monteforte, Hanko Hirata, Carmem Gottfried, Rosario Donato, Soraya Smaili, Carlos-Alberto Gonçalves
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
S100B secretion
calcium signaling
astrocytes
Online Access:https://www.mdpi.com/1422-0067/24/23/16576

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