Neutrophil Extracellular Traps Induce Tissue-Invasive Monocytes in Granulomatosis With Polyangiitis

Neutrophil Extracellular Traps Induce Tissue-Invasive Monocytes in Granulomatosis With Polyangiitis

Objective: Granulomatosis with polyangiitis (GPA) is a multi-organ vasculitic syndrome typically associated with neutrophil extracellular trap (NET) formation and aggressive tissue inflammation. Manifestations in head and neck (H&N) GPA include septal perforations, saddle-nose deformities, b...

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Bibliographic Details
Main Authors: Mitsuhiro Akiyama, Markus Zeisbrich, Nour Ibrahim, Shozo Ohtsuki, Gerald J. Berry, Peter H. Hwang, Jörg J. Goronzy, Cornelia M. Weyand
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
granulomatosis with polyangiitis
NETosis
S100A9
cartilage destruction
bone destruction
matrix metalloproteinases
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02617/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02617/full

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