Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs

Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs

ABSTRACT Spike-receptor interaction is a critical determinant for the host range of coronaviruses. Here, we investigated all the five World Health Organization-designated variants of concern (VOC), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529), fo...

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Bibliographic Details
Main Authors: Weitong Yao, Yujun Li, Danting Ma, Xudong Hou, Haimin Wang, Xiaojuan Tang, Dechun Cheng, He Zhang, Chengzhi Du, Hong Pan, Chao Li, Hua Lin, Mengsi Sun, Qiang Ding, Yingjie Wang, Jiali Gao, Guocai Zhong
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
variant of concern
Omicron
ACE2
host range
mouse
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02676-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02676-23

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