Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels

Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels

Obesity is a health concern worldwide, and its onset is multifactorial. In addition to metabolic syndrome, a high-fat diet induces many deleterious downstream effects, such as chronic systemic inflammation, a loss of gut barrier integrity, and gut microbial dysbiosis, with a reduction of many butyra...

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Bibliographic Details
Main Authors: Carmen Avagliano, Carmen De Caro, Mariarosaria Cuozzo, Fabrizio Maria Liguori, Giovanna La Rana, Laura Micheli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Orlando Paciello, Roberto Russo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
gut–liver axis
inflammation
phaseolamin
butyrate
peroxisome proliferator-activated receptor
intestinal barrier integrity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.930832/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.930832/full

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