Modification of a natural diterpene and its antitumor mechanism: Promoting apoptosis, suppressing migration, and inhibiting angiogenesis

Modification of a natural diterpene and its antitumor mechanism: Promoting apoptosis, suppressing migration, and inhibiting angiogenesis

The synthesis or derivation of a series of structural analogues based on natural products is a common strategy for discovering antitumor drugs. As a unique natural diterpene derived from Trigonostemon howii, 3,4-seco-sonderianol (1) exhibited moderate cytotoxic effects. To improve the activity, a ne...

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Bibliographic Details
Main Authors: Yuhui Liu, Sibei Wang, Maoqin Peng, Jun Ma, Qi Zhang, Yuanqiang Guo, Jing Xu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Arabian Journal of Chemistry
Subjects:
3,4-seco-Sonderianol
Triphenylphosphonium modification
Mitochondrial targeting
Apoptosis and migration
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224000054

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http://www.sciencedirect.com/science/article/pii/S1878535224000054

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