Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival

Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival

ABSTRACTStaphylococcus aureus propensity for intracellular survival presents a challenge to effectively treat infection, with significant evidence suggesting S. aureus can hijack phagocytes for host dissemination, worsening clinical outcomes. Human polymorphonuclear neutrophils (hPMN) have been iden...

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Bibliographic Details
Main Authors: Emilio G. Vozza, Clíodhna M. Daly, Sinead A. O'Rourke, Hannah K. Fitzgerald, Aisling Dunne, Rachel M. McLoughlin
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
Staphylococcus aureus
intracellular pathogen
pentose phosphate pathway
metabolism
A2aR
adora2a
Online Access:https://journals.asm.org/doi/10.1128/mbio.02571-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02571-23

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