The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and interest in ANO1/TMEM16A arise from a decade long inve...

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Bibliographic Details
Main Authors: Yani Liu, Zongtao Liu, KeWei Wang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ca2+-activated Cl– channels (CaCCs)
ANO1
TMEM16A
CaCCinh-A01
T16Ainh-A01
Drug target
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308352

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http://www.sciencedirect.com/science/article/pii/S2211383520308352

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