Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Abstract Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing hundreds of hiPSCs derived from different individuals, we show the proportions of these pluripotent states vary considerably across lines. We discover 13 gene network modules (GNMs) and 13 regulatory n...

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Bibliographic Details
Main Authors: Timothy D. Arthur, Jennifer P. Nguyen, Agnieszka D’Antonio-Chronowska, Hiroko Matsui, Nayara S. Silva, Isaac N. Joshua, iPSCORE Consortium, André D. Luchessi, William W. Young Greenwald, Matteo D’Antonio, Martin F. Pera, Kelly A. Frazer
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45506-6

Internet

https://doi.org/10.1038/s41467-024-45506-6

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