Genetic Variation in <i>CYP2D6</i>, <i>UGT1A4</i>, <i>SLC6A2</i> and <i>SLCO1B1</i> Alters the Pharmacokinetics and Safety of Mirabegron

Genetic Variation in <i>CYP2D6</i>, <i>UGT1A4</i>, <i>SLC6A2</i> and <i>SLCO1B1</i> Alters the Pharmacokinetics and Safety of Mirabegron

Mirabegron is a drug used in overactive bladder (OAB) treatment. Genetic variation in pharmacogenes might alter its pharmacokinetics, affecting its efficacy and safety. This research aimed to analyze the impact of genetic variation on mirabegron pharmacokinetics and safety. Volunteers from three bio...

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Bibliographic Details
Main Authors: Paula Soria-Chacartegui, Patricia Cendoya-Ramiro, Eva González-Iglesias, Samuel Martín-Vílchez, Andrea Rodríguez-Lopez, Gina Mejía-Abril, Manuel Román, Sergio Luquero-Bueno, Dolores Ochoa, Francisco Abad-Santos
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceutics
Subjects:
mirabegron
pharmacogenetics
<i>CYP2D6</i>
overactive bladder
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/16/8/1077

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https://www.mdpi.com/1999-4923/16/8/1077

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