Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway

Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing unremitting extracellular matrix deposition. Transforming growth factor-β (TGF-β) superfamily involves bone morphogenetic proteins (BMPs) and TGF-β, and the balance between the activation of TGF-β-dependent SMADs (Smad2/3) and...

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Bibliographic Details
Main Authors: Caijuan Huan, Wangting Xu, Yaru Liu, Kexin Ruan, Yueli Shi, Hongqiang Cheng, Xue Zhang, Yuehai Ke, Jianying Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
IPF (idiopathic pulmonary fibrosis)
gremlin2
BMP antagonists
P-smad1
fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.683267/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.683267/full

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