Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for poten...

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Bibliographic Details
Main Authors: Tong Liu, Deli Song, Jianzeng Dong, Pinghui Zhu, Jie Liu, Wei Liu, Xiaohai Ma, Lei Zhao, Shukuan Ling
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00238/full