Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model
Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer, with over half of patients presenting with metastatic PDAC at diagnosis. Most patients receive conventional chemotherapy which invariably faces resistance, and a key facilitator in this is the PDAC stroma which acts as a functional med...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/21/1/32 |
| _version_ | 1797595727993503744 |
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| author | Marianne Best Debashis Sarker Claire M. Wells |
| author_facet | Marianne Best Debashis Sarker Claire M. Wells |
| author_sort | Marianne Best |
| collection | DOAJ |
| description | Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer, with over half of patients presenting with metastatic PDAC at diagnosis. Most patients receive conventional chemotherapy which invariably faces resistance, and a key facilitator in this is the PDAC stroma which acts as a functional mediator of disease progression through bilateral crosstalk between stromal cells and cancer cells. ‘Migrastatics’ are a new drug class which target cell migration pathway effector proteins to attenuate cancer cell invasion. Improvement in PDAC treatment strategy is well-overdue and migrastatics as adjuvant therapy is one avenue gaining traction. The p21-activated kinase (PAK) family is frequently overexpressed and/or amplified in PDAC where it regulates cytoskeletal actin contractility as well as transcription. Pre-clinical PAK inhibitors have shown reduced PDAC cell invasion in vitro, yet it is unknown how the PDAC stromal cells would respond to a PAK inhibitor and how this could consequently affect PDAC invasion. My PhD project investigates the Pancreatic stellate cell response to PAK inhibition. |
| first_indexed | 2024-03-11T02:41:29Z |
| format | Article |
| id | doaj.art-16d99e42b1ce422a8217d0de70e696a2 |
| institution | Directory Open Access Journal |
| issn | 2673-9976 |
| language | English |
| last_indexed | 2024-03-11T02:41:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj.art-16d99e42b1ce422a8217d0de70e696a22023-11-18T09:34:17ZengMDPI AGBiology and Life Sciences Forum2673-99762023-04-012113210.3390/blsf2023021032Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion ModelMarianne Best0Debashis Sarker1Claire M. Wells2School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 1UL, UKGuy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UKSchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 1UL, UKPancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer, with over half of patients presenting with metastatic PDAC at diagnosis. Most patients receive conventional chemotherapy which invariably faces resistance, and a key facilitator in this is the PDAC stroma which acts as a functional mediator of disease progression through bilateral crosstalk between stromal cells and cancer cells. ‘Migrastatics’ are a new drug class which target cell migration pathway effector proteins to attenuate cancer cell invasion. Improvement in PDAC treatment strategy is well-overdue and migrastatics as adjuvant therapy is one avenue gaining traction. The p21-activated kinase (PAK) family is frequently overexpressed and/or amplified in PDAC where it regulates cytoskeletal actin contractility as well as transcription. Pre-clinical PAK inhibitors have shown reduced PDAC cell invasion in vitro, yet it is unknown how the PDAC stromal cells would respond to a PAK inhibitor and how this could consequently affect PDAC invasion. My PhD project investigates the Pancreatic stellate cell response to PAK inhibition.https://www.mdpi.com/2673-9976/21/1/32pancreatic cancercell migrationcell invasionp21-activated kinases (PAKs)kinase inhibitorsactomyosin contractility |
| spellingShingle | Marianne Best Debashis Sarker Claire M. Wells Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model Biology and Life Sciences Forum pancreatic cancer cell migration cell invasion p21-activated kinases (PAKs) kinase inhibitors actomyosin contractility |
| title | Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model |
| title_full | Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model |
| title_fullStr | Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model |
| title_full_unstemmed | Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model |
| title_short | Exploring the Effect of PAK Inhibition in a 3D Pancreatic Cancer Invasion Model |
| title_sort | exploring the effect of pak inhibition in a 3d pancreatic cancer invasion model |
| topic | pancreatic cancer cell migration cell invasion p21-activated kinases (PAKs) kinase inhibitors actomyosin contractility |
| url | https://www.mdpi.com/2673-9976/21/1/32 |
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