Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

Abstract Background Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous sys...

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Bibliographic Details
Main Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang, Jialin Zheng
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Translational Neurodegeneration
Subjects:
Glutaminase 1
Protein expression
Enzyme activity
Online Access:http://link.springer.com/article/10.1186/s40035-017-0080-x

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http://link.springer.com/article/10.1186/s40035-017-0080-x

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