Immunohistochemistry of colorectal cancer biomarker phosphorylation requires controlled tissue fixation.

Phosphorylated signaling molecules are biomarkers of cancer pathophysiology and resistance to therapy, but because phosphoprotein analytes are often labile, poorly controlled clinical laboratory practices could prevent translation of research findings in this area from the bench to the bedside. We t...

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Bibliographic Details
Main Authors: Abbey P Theiss, David Chafin, Daniel R Bauer, Thomas M Grogan, Geoffrey S Baird
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237459?pdf=render