GABA and Fermented <i>Curcuma longa</i> L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice

GABA and Fermented <i>Curcuma longa</i> L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice

<i>Gamma</i>-<i>aminobutyric acid</i> (GABA) is a natural amino acid with antioxidant activity and is often considered to have therapeutic potential against obesity. Obesity has long been linked to ROS and ER stress, but the effect of GABA on the ROS-associated ER stress axis...

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Bibliographic Details
Main Authors: Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Yu-Mi Kim, Gi-Hyun Jang, Chang-Hwan Seok, Yun-Geum-Sang Gwak, Junghyun Lim, Junghyun Kim, Han-Jung Chae
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
NADPH oxidase
IRE1α
SIRT1
decay
obesity
Online Access:https://www.mdpi.com/2072-6643/14/8/1680

Internet

https://www.mdpi.com/2072-6643/14/8/1680

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