Phosphate Metabolic Inhibition Contributes to Irradiation-Induced Myelosuppression through Dampening Hematopoietic Stem Cell Survival

Phosphate Metabolic Inhibition Contributes to Irradiation-Induced Myelosuppression through Dampening Hematopoietic Stem Cell Survival

Myelosuppression is a common and intractable side effect of cancer therapies including radiotherapy and chemotherapy, while the underlying mechanism remains incompletely understood. Here, using a mouse model of radiotherapy-induced myelosuppression, we show that inorganic phosphate (Pi) metabolism i...

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Bibliographic Details
Main Authors: Yiding Wu, Weinian Liao, Jun Chen, Chaonan Liu, Shuzhen Zhang, Kuan Yu, Xinmiao Wang, Mo Chen, Song Wang, Xinze Ran, Yongping Su, Tianmin Cheng, Junping Wang, Changhong Du
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Nutrients
Subjects:
inorganic phosphate
myelosuppression
hematopoietic stem cell
irradiation
apoptosis
Online Access:https://www.mdpi.com/2072-6643/14/16/3395

Internet

https://www.mdpi.com/2072-6643/14/16/3395

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