A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity

A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity

The blood-brain barrier (BBB) restricts paracellular and transcellular diffusion of compounds and is part of a dynamic multicellular structure known as the “neurovascular unit” (NVU), which strictly regulates the brain homeostasis and microenvironment. Several neuropathological conditions (e.g., Par...

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Bibliographic Details
Main Authors: Chiara Barberio, Aimee Withers, Yash Mishra, Pierre-Olivier Couraud, Ignacio A. Romero, Babette Weksler, Róisín M. Owens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurovascular unit (NVU) model
blood-brain barrier (BBB)
Transwell
in vitro
human immortalized cell lines
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1065193/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1065193/full

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