Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury

Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury

Axon injury in the peripheral nervous system (PNS) induces a regeneration-associated gene (RAG) response. Atf3 (activating transcription factor 3) is such a RAG and ATF3's transcriptional activity might induce ‘effector’ RAGs (e.g. small proline rich protein 1a (Sprr1a), Galanin (Gal), growth-a...

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Bibliographic Details
Main Authors: Manuel Gey, Renate Wanner, Corinna Schilling, Maria T. Pedro, Daniela Sinske, Bernd Knöll
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
atf3
axon regeneration
facial nerve
neuropeptide
rag
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160091

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160091

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