Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

Background and purpose: Histone deacetylation is one of the essential cellular pathways in the growth and spread of cancer, so the design of histone deacetylase (HDAC) inhibitors as anticancer agents is of great importance in pharmaceutical chemistry. Here, a series of indole acylhydrazone derivativ...

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Bibliographic Details
Main Authors: Niloofar Naghi-Ganji, Lotfollah Saghaei, Farial Tavakoli, Vajihe Azimian, Mina Mirian, Hajar Sirous, Mahboubeh Rostami
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
acylhydrazone; cytotoxicity; hdac inhibitor; indole; molecular docking 4-pyridone
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=5;spage=572;epage=584;aulast=Naghi-Ganji

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=5;spage=572;epage=584;aulast=Naghi-Ganji

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