Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity

Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity

BackgroundVestibular side effects such as dizziness and vertigo can be a limitation for some antibiotics commonly used to treat acne, rosacea, and other dermatology indications.ObjectiveUnlike minocycline, which is a second-generation tetracycline, sarecycline, a narrow-spectrum third-generation tet...

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Bibliographic Details
Main Authors: Ayman Grada, James Q. Del Rosso, Angela Y. Moore, Linda Stein Gold, Julie Harper, Giovanni Damiani, Katharina Shaw, Sabine Obagi, Raidah J. Salem, S. Ken Tanaka, Christopher G. Bunick
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Medicine
Subjects:
acne vulgaris
sarecycline
minocycline
dizziness
blood-brain barrier
lipophilicity
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1033980/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.1033980/full

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