Lrp5 p.Val667Met Variant Compromises Bone Mineral Density and Matrix Properties in Osteoporosis

Lrp5 p.Val667Met Variant Compromises Bone Mineral Density and Matrix Properties in Osteoporosis

ABSTRACT Early‐onset osteoporosis (EOOP) has been associated with several genes, including LRP5, coding for a coreceptor in the Wnt pathway. Variants in LRP5 were also described in osteoporosis pseudoglioma syndrome, combining severe osteoporosis and eye abnormalities. Genomewide‐association studies...

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Bibliographic Details
Main Authors: Stéphanie Fabre, Morgane Bourmaud, Guillaume Mabilleau, Ruben Goulet, Aude Couturier, Alexandre Dentel, Serge Picaud, Thomas Funck‐Brentano, Corinne Collet, Martine Cohen‐Solal
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:JBMR Plus
Subjects:
bone density
collagene
fracture
Lrp5
Wnt
Online Access:https://doi.org/10.1002/jbm4.10741

Internet

https://doi.org/10.1002/jbm4.10741

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