Challenging a bioinformatic tool’s ability to detect microbial contaminants using in silico whole genome sequencing data

Challenging a bioinformatic tool’s ability to detect microbial contaminants using in silico whole genome sequencing data

High sensitivity methods such as next generation sequencing and polymerase chain reaction (PCR) are adversely impacted by organismal and DNA contaminants. Current methods for detecting contaminants in microbial materials (genomic DNA and cultures) are not sensitive enough and require either a known...

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Bibliographic Details
Main Authors: Nathan D. Olson, Justin M. Zook, Jayne B. Morrow, Nancy J. Lin
Format: Article
Language:English
Published: PeerJ Inc. 2017-09-01
Series:PeerJ
Subjects:
Genomic purity
Whole genome sequencing
Bioinformatics
Biodetection
Microbial materials
Reference materials
Online Access:https://peerj.com/articles/3729.pdf

Internet

https://peerj.com/articles/3729.pdf

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