Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells

Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells

Lung adenocarcinoma is the most common pathological type of lung cancer with poor patient outcomes; therefore, developing novel therapeutic agents is critically needed. Andrographolide (AD), a major active component derived from the traditional Chinese medicine (TCM) Andrographis paniculate, is a po...

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Bibliographic Details
Main Authors: Junqian Zhang, Chunjie Li, Li Zhang, Yongqing Heng, Tong Xu, Yunjing Zhang, Xihui Chen, Robert M Hoffman, Lijun Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
TCM
andrographolide
lung adenocarcinoma
apoptosis
ATF4
noxa
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.680589/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.680589/full

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