Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance

ABSTRACT The World Health Organization reports that antibiotic-resistant pathogens represent an imminent global health disaster for the 21st century. Gram-positive superbugs threaten to breach last-line antibiotic treatment, and the pharmaceutical industry antibiotic development pipeline is waning....

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Bibliographic Details
Main Authors: Lisa Bohlmann, David M. P. De Oliveira, Ibrahim M. El-Deeb, Erin B. Brazel, Nichaela Harbison-Price, Cheryl-lynn Y. Ong, Tania Rivera-Hernandez, Scott A. Ferguson, Amanda J. Cork, Minh-Duy Phan, Amelia T. Soderholm, Mark R. Davies, Graeme R. Nimmo, Gordon Dougan, Mark A. Schembri, Gregory M. Cook, Alastair G. McEwan, Mark von Itzstein, Christopher A. McDevitt, Mark J. Walker
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
Enterococcus faecium
Staphylococcus aureus
Streptococcus pyogenes
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/mBio.02391-18

Internet

https://journals.asm.org/doi/10.1128/mBio.02391-18

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