Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917.

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917.

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Enteric microbial pathogens, including Escherichia coli, Shigella and Cryptosporidium species, take a particularly heavy toll in low-income countries and are highly associated with infant mortality. We describe here a means to display anti-infective agents on the surface of a probiotic bacterium. Be...

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Bibliographic Details
Main Authors: Ilia Gelfat, Yousuf Aqeel, Jacqueline M Tremblay, Justyna J Jaskiewicz, Anishma Shrestha, James N Lee, Shenglan Hu, Xi Qian, Loranne Magoun, Abhineet Sheoran, Daniela Bedenice, Colter Giem, Avinash Manjula-Basavanna, Amanda R Pulsifer, Hann X Tu, Xiaoli Li, Marilyn L Minus, Marcia S Osburne, Saul Tzipori, Charles B Shoemaker, John M Leong, Neel S Joshi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010713

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https://doi.org/10.1371/journal.ppat.1010713

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