Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.

Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 WA1/2020 challenge and are therefore useful models of COVID-19 pathogenesis and prevention with vaccines. Recent studies have shown that SARS-CoV-2 infection stimulates type I interferon, myeloid, and inflammatory signatures...

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Bibliographic Details
Main Authors: Malika Aid, Samuel J Vidal, Cesar Piedra-Mora, Sarah Ducat, Chi N Chan, Stephen Bondoc, Alessandro Colarusso, Carly E Starke, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D Estes, Amanda J Martinot, Dan H Barouch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009990

Internet

https://doi.org/10.1371/journal.ppat.1009990

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