Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells

Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells

Abstract Background As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen. Methods Co-i...

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Bibliographic Details
Main Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi, Jianxiang Wang
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Cancer
Subjects:
iASPP
Sertad1
P53
Apoptosis
Leukemic cell
Online Access:http://link.springer.com/article/10.1186/s12885-017-3787-2

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http://link.springer.com/article/10.1186/s12885-017-3787-2

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