Genetic correction of induced pluripotent stem cells from a DFNA36 patient results in morphologic and functional recovery of derived hair cell-like cells

Genetic correction of induced pluripotent stem cells from a DFNA36 patient results in morphologic and functional recovery of derived hair cell-like cells

Abstract Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. Here, we investigated the differentiation, mor...

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Bibliographic Details
Main Authors: Yi Luo, Kaiwen Wu, Xiaolong Zhang, Hongyang Wang, Qiuju Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Stem Cell Research & Therapy
Subjects:
Induced pluripotent stem cells
TMC1
Hair cells
Differentiation
Whole-cell patch-clamp
Online Access:https://doi.org/10.1186/s13287-023-03617-9

Internet

https://doi.org/10.1186/s13287-023-03617-9

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