GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice

GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice

Abstract Background Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects learning and memory remains unclear. Methods The chronic stress mouse mod...

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Bibliographic Details
Main Authors: Xue Wang, Yuhan Wu, Yingrui Tian, Hui Hu, Yun Zhao, Binghua Xue, Zhaowei Sun, Aijun Wei, Fang Xie, Ling-Jia Qian
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell & Bioscience
Subjects:
Chronic stress
Microglia
Proinflammatory activation
GLUT1
Spatial memory dysfunction
Online Access:https://doi.org/10.1186/s13578-024-01229-1

Internet

https://doi.org/10.1186/s13578-024-01229-1

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