Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study

The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic f...

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Bibliographic Details
Main Authors: Juan Carlos Quintana-Castillo, Leidy Johana Vargas, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez, Juan Carlos Alarcón
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/10/2/85
Description
Summary:The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity.
ISSN:2072-6651