Celastrus orbiculatus Thunb. extracts and celastrol alleviate NAFLD by preserving mitochondrial function through activating the FGF21/AMPK/PGC-1α pathway

Celastrus orbiculatus Thunb. extracts and celastrol alleviate NAFLD by preserving mitochondrial function through activating the FGF21/AMPK/PGC-1α pathway

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease globally, characterized by the accumulation of lipids, oxidative stress, and mitochondrial dysfunction in the liver. Celastrus orbiculatus Thunb. (COT) and its active compound celastrol (CEL) have demonstrated an...

Full description

Bibliographic Details
Main Authors: Junli Xue, Yunchao Liu, Boyan Liu, Xiubin Jia, Xinsheng Fang, Shucun Qin, Ying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Pharmacology
Subjects:
Celastrus orbiculatus Thunb.
celastrol
NAFLD
mitochondrial function
FGF21/AMPK/PGC-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1444117/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1444117/full

Similar Items