Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer

Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer

Abstract Background The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosy...

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Bibliographic Details
Main Authors: Sandhya Yadav, Somnath D. Bhagat, Amit Gupta, Atul Samaiya, Aasheesh Srivastava, Sanjeev Shukla
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Curcumin
Head and neck cancer
PKM
Warburg effect
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s12885-019-6257-1

Internet

http://link.springer.com/article/10.1186/s12885-019-6257-1

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