Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer

Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers and remains a major unsolved health problem. While pancreatic ductal adenocarcinoma (PDAC) is associated with driver mutations in only four major genes (KRAS, TP53, SMAD4, and CDKN2A), every tumor differs in its molecular landscape, histology, and pr...

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Bibliographic Details
Main Authors: Sushmitha Sankarasubramanian, Ulrike Pfohl, Christian R. A. Regenbrecht, Christoph Reinhard, Lena Wedeken
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pancreatic ductal adenocarcinoma (PDAC)
tumor heterogeneity
KRAS
3D cell culture models
personalized medicine
patient-derived tumor organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.760705/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.760705/full

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