Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice

Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice

Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization. mRNA vaccines allow for easy antigen modification, enabling rapi...

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Bibliographic Details
Main Authors: Alec W. Freyn, Matthew Pine, Victoria C. Rosado, Marcel Benz, Hiromi Muramatsu, Mitchell Beattie, Ying K. Tam, Florian Krammer, Peter Palese, Raffael Nachbagauer, Meagan McMahon, Norbert Pardi
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
mRNA
nucleoside-modified
vaccine
influenza
universal
antigen
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001054

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121001054

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