Transcription factor Ap2b regulates the mouse autosomal recessive polycystic kidney disease genes, Pkhd1 and Cys1

Transcription factor Ap2b regulates the mouse autosomal recessive polycystic kidney disease genes, Pkhd1 and Cys1

Transcription factor Ap2b (TFAP2B), an AP-2 family transcription factor, binds to the palindromic consensus DNA sequence, 5′-GCCN3-5GGC-3’. Mice lacking functional Tfap2b gene die in the perinatal or neonatal period with cystic dilatation of the kidney distal tubules and collecting ducts, a phenotyp...

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Bibliographic Details
Main Authors: Maoqing Wu, Naoe Harafuji, Amber K. O’Connor, Ljubica Caldovic, Lisa M. Guay-Woodford
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
autosomal recessive polycystic kidney disease (ARPKD)
Cys1
Pkhd1
Tfap2b
TFAP2B
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.946344/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.946344/full

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