Transcription factor Ap2b regulates the mouse autosomal recessive polycystic kidney disease genes, Pkhd1 and Cys1
Transcription factor Ap2b (TFAP2B), an AP-2 family transcription factor, binds to the palindromic consensus DNA sequence, 5′-GCCN3-5GGC-3’. Mice lacking functional Tfap2b gene die in the perinatal or neonatal period with cystic dilatation of the kidney distal tubules and collecting ducts, a phenotyp...
Main Authors: | Maoqing Wu, Naoe Harafuji, Amber K. O’Connor, Ljubica Caldovic, Lisa M. Guay-Woodford |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-01-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.946344/full |
Similar Items
-
Differential regulation of MYC expression by PKHD1/Pkhd1 in human and mouse kidneys: phenotypic implications for recessive polycystic kidney disease
by: Naoe Harafuji, et al.
Published: (2023-11-01) -
Distinct activities of Tfap2A and Tfap2B in the specification of GABAergic interneurons in the developing cerebellum
by: Zainolabidin, Norliyana, et al.
Published: (2018) -
Clinical and genetic characteristics of autosomal recessive polycystic kidney disease in Oman
by: Intisar Al Alawi, et al.
Published: (2020-08-01) -
A novel PKHD1 splicing variant identified in a fetus with autosomal recessive polycystic kidney disease
by: Mingzhu Miao, et al.
Published: (2023-06-01) -
Design of two ongoing clinical trials of tolvaptan in the treatment of pediatric patients with autosomal recessive polycystic kidney disease
by: Djalila Mekahli, et al.
Published: (2023-02-01)