Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis

Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis

Abstract Background Papillary thyroid carcinoma (PTC) is one of the most common forms of thyroid cancer with a cure rate of over 90% after surgery. However, aggressive forms may still occur, and personalized therapeutic strategies are increasingly required. Methods We performed integrated genomic an...

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Bibliographic Details
Main Authors: Emilie Renaud, Kristina Riegel, Rossana Romero, Kushal Suryamohan, Ute Distler, Stefan Tenzer, Arno Schad, Thomas J. Musholt, Krishnaraj Rajalingam
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Molecular Cancer
Subjects:
Papillary thyroid cancer
PTC
BAIAP2L1-BRAF
TRIM25
PKCδ
Precision medicine
Online Access:https://doi.org/10.1186/s12943-022-01665-y

Internet

https://doi.org/10.1186/s12943-022-01665-y

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