Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis

Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis

Background Although trials suggest that anti‐inflammatory approaches targeting interleukin (IL)‐6 signaling can reduce cardiovascular risk, it remains unknown whether targeting IL‐6 signaling could reduce risk additively to low‐density lipoprotein cholesterol (LDL‐C) lowering. Here, we assess intera...

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Bibliographic Details
Main Authors: Marios K. Georgakis, Rainer Malik, Stephen Burgess, Martin Dichgans
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
inflammation
interleukin‐6
low‐density lipoprotein
Mendelian randomization
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023277

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023277

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