Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture

Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture

Background: Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) remains a treatment-resistance disease with limited response to immunotherapy. While T cells in HNSCC are known to display phenotypic dysfunction, whether they retain rescuable functional capacity and tumor...

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Bibliographic Details
Main Authors: Joseph Zenga, Musaddiq Awan, Anne Frei, Jamie Foeckler, Rachel Kuehn, Oscar Villareal Espinosa, Jennifer Bruening, Becky Massey, Stuart Wong, Aditya Shreenivas, Monica Shukla, Julia Kasprzak, Yunguang Sun, Md Shaheduzzaman, Fanghong Chen, Tyce Kearl, Heather A. Himburg
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Translational Oncology
Subjects:
Head and neck cancer
T cell
Tumor-infiltrating lymphocyte
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324000251

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http://www.sciencedirect.com/science/article/pii/S1936523324000251

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