Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia

Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia

Ischemic strokes are caused by a reduction in cerebral blood flow and both the ischemic period and subsequent reperfusion induce brain injury, with different tissue damage depending on the severity of the ischemic insult, its duration, and the particular areas of the brain affected. In those areas v...

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Bibliographic Details
Main Authors: Emma Martínez-Alonso, Natalia Guerra-Pérez, Alejandro Escobar-Peso, Lorena Peracho, Rocío Vera-Lechuga, Antonio Cruz-Culebras, Jaime Masjuan, Alberto Alcázar
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
cerebral ischemia
eIF4E
eIF4G1
protein synthesis regulation
protein phosphorylation
neuronal death
Online Access:https://www.mdpi.com/1422-0067/23/3/1830

Internet

https://www.mdpi.com/1422-0067/23/3/1830

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