Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression and decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages as compared to other opiates in clinical trials, possibly du...

Full description

Bibliographic Details
Main Authors: Liang Ye, Chunmei Li, Wanglin Jiang, Yifei Yang, Wenyan Wang, Haibo Zhu, Zhengping Hu, Ning Li, Xiaobo Cen, Hongbo Wang, Jingwei Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
LPM3480392
a full μ-opioid receptor biased agonist
pain
subacute toxicity
rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1218380/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1218380/full

Similar Items