Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer

Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer

Abstract Background New treatment options for ovarian cancer are urgently required. Tumor-associated macrophages (TAMs) are an attractive target for therapy; repolarizing TAMs from M2 (pro-tumor) to M1 (anti-tumor) phenotypes represents an important therapeutic goal. We have previously shown that up...

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Bibliographic Details
Main Authors: Alyssa A. Hoover, Demetra H. Hufnagel, Whitney Harris, Kennady Bullock, Evan B. Glass, Esther Liu, Whitney Barham, Marta A. Crispens, Dineo Khabele, Todd D. Giorgio, Andrew J. Wilson, Fiona E. Yull
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
NF-κB
Ovarian cancer
Tumor immunology
Online Access:http://link.springer.com/article/10.1186/s12885-020-07450-8

Internet

http://link.springer.com/article/10.1186/s12885-020-07450-8

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