Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida auris

Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida auris

ABSTRACT Fungal infections are a global threat, but treatments are limited due to a paucity in antifungal drug targets and the emergence of drug-resistant fungi such as Candida auris. Metabolic adaptations enable microbial growth in nutrient-scarce host niches, and they further control immune respon...

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Bibliographic Details
Main Authors: Claudia Simm, Harshini Weerasinghe, David R. Thomas, Paul F. Harrison, Hayley J. Newton, Traude H. Beilharz, Ana Traven
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
Candida auris
antifungal agents
fungal pathogens
iron
metabolism
mitochondrial metabolism
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00100-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00100-22

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