Cellular Activation of the Self-Quenched Fluorescent Reporter Probe in Tumor Microenvironment

Cellular Activation of the Self-Quenched Fluorescent Reporter Probe in Tumor Microenvironment

The effect of intralysosomal proteolysis of near-infrared fluorescent (NIRF) self-quenched macromolecular probe (PGC-Cy5.5) has been previously reported and used for tumor imaging. Here we demonstrate that proteolysis can be detected noninvasively in vivo at the cellular level. A codetection of GFP...

Full description

Bibliographic Details
Main Authors: Alexei A. Bogdanov, Jr., Charles P. Lin, Maria Simonova, Lars Matuszewski, Ralph Weissleder
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
tumor
cathepsin
microscopy confocal
fluorescent probe
indocyanine
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558602800161

Internet

http://www.sciencedirect.com/science/article/pii/S1476558602800161

Similar Items