Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin–Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics

Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin–Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics

Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase t...

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Bibliographic Details
Main Authors: Anca Hermenean, Eleftheria Dossi, Alex Hamilton, Maria Consiglia Trotta, Marina Russo, Caterina Claudia Lepre, Csilla Sajtos, Ágnes Rusznyák, Judit Váradi, Ildikó Bácskay, István Budai, Michele D’Amico, Ferenc Fenyvesi
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
OTX008
chrysin
sulfobutylated β-cyclodextrin
ternary complex
solubilization mechanism
molecular simulation
Online Access:https://www.mdpi.com/1424-8247/17/1/107

Internet

https://www.mdpi.com/1424-8247/17/1/107

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