Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing. Because SNORD115 genes are deleted in most patients with the Prader-Willi syndrome (PWS), diminished HTR2C...

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Bibliographic Details
Main Authors: Jade Hebras, Virginie Marty, Jean Personnaz, Pascale Mercier, Nicolai Krogh, Henrik Nielsen, Marion Aguirrebengoa, Hervé Seitz, Jean-Phillipe Pradere, Bruno P Guiard, Jérôme Cavaille
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
snoRNA
prader-willi syndrome
serotonin 2c receptor
RNA editing
alternative RNA splicing
eating disorder
Online Access:https://elifesciences.org/articles/60862

Internet

https://elifesciences.org/articles/60862

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