Chronic stress induces CD99, suppresses autophagy, and affects spontaneous adipogenesis in human bone marrow stromal cells

Chronic stress induces CD99, suppresses autophagy, and affects spontaneous adipogenesis in human bone marrow stromal cells

Abstract Background Bone marrow-derived mesenchymal stromal cells (MSCs) are multipotent cells with a high constitutive level of autophagy and low expression of CD99. Under certain conditions, MSCs may develop tumorigenic properties. However, these transformation-induced conditions are largely unkno...

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Bibliographic Details
Main Authors: Zvenyslava Husak, Michael N. Dworzak
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Stem Cell Research & Therapy
Subjects:
Bone marrow stromal cells
CD99
Stress
MSC
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13287-017-0532-3

Internet

http://link.springer.com/article/10.1186/s13287-017-0532-3

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